Proteomics

Dataset Information

0

Control of protein accumulation by the LON2 peroxisomal protease and autophagy


ABSTRACT: Peroxisomes are membrane-bound eukaryotic organelles that house essential metabolic pathways. Many of these pathways generate damaging reactive oxygen species (ROS) that also function as signaling molecules. In Arabidopsis thaliana, damaged or obsolete peroxisomal proteins can be degraded by the LON2 peroxisomal protease. In addition, peroxisomes can be entirely degraded through a specialized form of autophagy (pexophagy), a process that is amplified when LON2 is dysfunctional. As a first step towards identifying LON2 substrates, we used proteomic analysis to compare proteins that accumulate when LON2 is dysfunctional in the presence and absence of autophagy.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress)

TISSUE(S): Shoot

SUBMITTER: Bonnie Bartel  

LAB HEAD: Bonnie Bartel

PROVIDER: PXD022921 | Pride | 2025-05-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
201015_At_lon2_atg2_Full_Analysis.msf Msf
201015_At_lon2_atg2_Full_Analysis.mzML Mzml
201015_At_lon2_atg2_Full_Analysis.mzid.gz Mzid
201015_At_lon2_atg2_Full_Analysis.pep.xml Pepxml
Col-0_1_t1.raw Raw
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Publications

Global impacts of peroxisome and pexophagy dysfunction revealed through multi-omics analyses of lon2 and atg2 mutants.

Muhammad DurreShahwar D   Clark Natalie M NM   Tharp Nathan E NE   Chatt Elizabeth C EC   Vierstra Richard D RD   Bartel Bonnie B  

The Plant journal : for cell and molecular biology 20241111 6


Peroxisomes house diverse metabolic pathways that are essential for plant and animal survival, including enzymes that produce or inactivate toxic byproducts. Despite the importance of peroxisomes and their collaborations with other organelles, the mechanisms that trigger or prevent peroxisome turnover and the cellular impacts of impaired peroxisomes are incompletely understood. When Arabidopsis thaliana LON2, a peroxisomal protein with chaperone and protease capacity, is disrupted, metabolic dys  ...[more]

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