Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Neutrophil
DISEASE(S): Covid-19
SUBMITTER: Nicholas Riley
LAB HEAD: Carolyn Bertozzi
PROVIDER: PXD022990 | Pride | 2021-07-28
REPOSITORIES: Pride
Delaveris Corleone S CS Wilk Aaron J AJ Riley Nicholas M NM Stark Jessica C JC Yang Samuel S SS Rogers Angela J AJ Ranganath Thanmayi T Nadeau Kari C KC Blish Catherine A CA Bertozzi Carolyn R CR
ChemRxiv : the preprint server for chemistry 20201217
Severe cases of coronavirus disease 2019 (COVID-19), caused by infection with SARS-Cov-2, are characterized by a hyperinflammatory immune response that leads to numerous complications. Production of proinflammatory neutrophil extracellular traps (NETs) has been suggested to be a key factor in inducing a hyperinflammatory signaling cascade, allegedly causing both pulmonary tissue damage and peripheral inflammation. Accordingly, therapeutic blockage of neutrophil activation and NETosis, the cell d ...[more]