Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Cell Suspension Culture, Epithelial Cell, Cell Culture
DISEASE(S): Lymphoma,Breast Cancer
SUBMITTER: Bogdan Florea
LAB HEAD: Lenka Besse
PROVIDER: PXD023260 | Pride | 2021-11-02
REPOSITORIES: Pride
Cancer research 20210622 17
The HIV-protease inhibitor nelfinavir has shown broad anticancer activity in various preclinical and clinical contexts. In patients with advanced, proteasome inhibitor (PI)-refractory multiple myeloma, nelfinavir-based therapy resulted in 65% partial response or better, suggesting that this may be a highly active chemotherapeutic option in this setting. The broad anticancer mechanism of action of nelfinavir implies that it interferes with fundamental aspects of cancer cell biology. We combined p ...[more]