Single-cell chromatin accessibility data using scATAC-seq

ABSTRACT: Cell-to-cell variation is a universal feature of life that impacts a wide range of biological phenomena, from developmental plasticity to tumor heterogeneity. While recent advances have improved our ability to document cellular phenotypic variation the fundamental mechanisms that generate variability from identical DNA sequences remain elusive. Here we reveal the landscape and principles of cellular DNA regulatory variation by developing a robust method for mapping the accessible genome of individual cells via assay of transposase accessible chromatin sequencing (ATAC-seq). Single-cell ATAC-seq (scATAC-seq) maps from hundreds of single-cells in aggregate closely resemble accessibility profiles from tens of millions of cells and provides insights into cell-to-cell variation. Accessibility v

ORGANISM(S): Mus musculus

SUBMITTER: Jason Buenrostro 

PROVIDER: E-GEOD-65360 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress