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Toxoplasma gondii Tgj1 Hsp40 protein interaction LC-MS/MS

ABSTRACT: We identified an Hsp40 Ydj1 / Hdj2 ortholog in T. gondii, which is involved in various biological roles in T. gondii as deduced from its interactome and analysis of the ΔCXXX mutant. Among these roles are differentiation and DNA damage, as well as metabolic pathways such as translation and energy generation.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Toxoplasma Gondii

TISSUE(S): Cell Culture

SUBMITTER: BIN DENG

LAB HEAD: Bin Deng

PROVIDER: PXD024656 | Pride | 2023-05-10

REPOSITORIES: Pride

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Analysis of the Interactome of the Toxoplasma gondii Tgj1 HSP40 Chaperone.

Munera López Jonathan J Alonso Andrés Mariano AM Figueras Maria Julia MJ Saldarriaga Cartagena Ana María AM Hortua Triana Miryam A MA Diambra Luis L Vanagas Laura L Deng Bin B Moreno Silvia N J SNJ Angel Sergio Oscar SO

Proteomes 20230301 1

Toxoplasma gondii is an obligate intracellular apicomplexan that causes toxoplasmosis in humans and animals. Central to its dissemination and pathogenicity is the ability to rapidly divide in the tachyzoite stage and infect any type of nucleated cell. Adaptation to different cell contexts requires high plasticity in which heat shock proteins (Hsps) could play a fundamental role. Tgj1 is a type I Hsp40 of T. gondii, an ortholog of the DNAJA1 group, which is essential during the tach ...[more]

PMID: 36976888

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