Dataset Information

The HSP40 chaperone Ydj1/DnaJA1 drives amyloid beta toxicity

ABSTRACT: Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD); however, the etiology of Abeta42 toxicity remains elusive. In a proteomic approach using a yeast model for intracellular Abeta42 toxicity, we here identify the HSP40 family member Ydj1, the yeast orthologue of human DnaJA1, as a crucial factor in Abeta42-mediated toxicity.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Joern Dengjel

LAB HEAD: Joern Dengjel

PROVIDER: PXD012612 | Pride | 2022-04-27

REPOSITORIES: Pride

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Publications

The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity.

Ring Julia J Tadic Jelena J Ristic Selena S Poglitsch Michael M Bergmann Martina M Radic Nemanja N Mossmann Dirk D Liang YongTian Y Maglione Marta M Jerkovic Andrea A Hajiraissi Roozbeh R Hanke Marcel M Küttner Victoria V Wolinski Heimo H Zimmermann Andreas A Domuz Trifunović Lana L Mikolasch Leonie L Moretti Daiana N DN Broeskamp Filomena F Westermayer Julia J Abraham Claudia C Schauer Simon S Dammbrueck Christopher C Hofer Sebastian J SJ Abdellatif Mahmoud M Grundmeier Guido G Kroemer Guido G Braun Ralf J RJ Hansen Niklas N Sommer Cornelia C Ninkovic Mirjana M Seba Sandra S Rockenfeller Patrick P Vögtle Friederike-Nora FN Dengjel Jörn J Meisinger Chris C Keller Adrian A Sigrist Stephan J SJ Eisenberg Tobias T Madeo Frank F

EMBO molecular medicine 20220404 5

Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer's disease (AD). However, the etiology of its noxious cellular effects remains elusive. In a combinatory genetic and proteomic approach using a yeast model to study aspects of intracellular Abeta42 toxicity, we here identify the HSP40 family member Ydj1, the yeast orthologue of human DnaJA1, as a crucial factor in Abeta42-mediated cell death. We demonstrate that Ydj1/DnaJA1 physically interacts with Abeta42 ( ...[more]

PMID: 35373908

Dataset Information

The HSP40 chaperone Ydj1/DnaJA1 drives amyloid beta toxicity

Publications

The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity.

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