Proteomics

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Proteome analysis of Lung tissue of mice bearing B16-F10-luc-G5 melanoma tumor with sleep fragmentation and with or with out the asdmistration of GL-pp


ABSTRACT: Proteome analysis of Lung tissue of mice bearing B16-F10-luc-G5 melanoma tumor with sleep fragmentation and with or with out the asdmistration of GL-pp. The mice were randomly divided into 4 groups: control group in general condition with no further treatment (CON group), tumor group with the burden of B16-F10-luc-G5 cells (Tumor group), T+SF group with SF and the burden of B16-F10-luc-G5 cells (T+SF group), and GL-pp group with SF, tumor cells burden, and the administration of 80 mg/kg GL-pp (GL-pp group). B16-F10-luc-G5 cells (5 × 1000000 cells/100 µL per mouse) were injected into the mice through the tail vein. The lung tissue of T+SF group and GL-pp group were analyzed by the proteome.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

SUBMITTER: Haocheng Xian  

LAB HEAD: Yan Pan

PROVIDER: PXD025171 | Pride | 2021-09-10

REPOSITORIES: Pride

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Publications

Antimetastatic Effects of <i>Ganoderma lucidum</i> Polysaccharide Peptide on B16-F10-luc-G5 Melanoma Mice With Sleep Fragmentation.

Xian Haocheng H   Li Jiayi J   Zhang Yimeng Y   Li Ditian D   Zhu Yinan Y   Li Siyan S   Tan Zhelun Z   Lin Zhibin Z   Li Xuejun X   Pan Yan Y  

Frontiers in pharmacology 20210708


<i>Ganoderma lucidum</i> (Lingzhi) polysaccharide peptide (GL-pp) is a component of the globally acknowledged traditional Chinese medicine <i>Ganoderma lucidum</i>; <i>Ganoderma lucidum</i> is known for its sedative, hypnotic, immune regulatory, antitumor, and other pharmacological effects. In recent years, sleep disorders have been linked to many diseases and human body disorders, including cancer. Some experimental studies in mice found that sleep fragmentation could promote tumor development  ...[more]

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