Comparison of human primordial oocyte follicles to ovarian somatic cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Ovary, Oocyte
SUBMITTER: 
Aida Rodriguez-Nuevo
LAB HEAD: Elvan Boke
PROVIDER: PXD025369 | Pride | 2022-05-09
REPOSITORIES: Pride
Publications
Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I.
Rodríguez-Nuevo Aida A Torres-Sanchez Ariadna A Duran Juan M JM De Guirior Cristian C Martínez-Zamora Maria Angeles MA Böke Elvan E
Nature 20220720 7920
Oocytes form before birth and remain viable for several decades before fertilization<sup>1</sup>. Although poor oocyte quality accounts for most female fertility problems, little is known about how oocytes maintain cellular fitness, or why their quality eventually declines with age<sup>2</sup>. Reactive oxygen species (ROS) produced as by-products of mitochondrial activity are associated with lower rates of fertilization and embryo survival<sup>3-5</sup>. Yet, how healthy oocytes balance essenti ...[more]
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