Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Skeletal Muscle Tissue, Muscle
DISEASE(S): Myotonic Dystrophy Type 1
SUBMITTER: Elizaveta Solovyeva
LAB HEAD: Sebastian Hoersch
PROVIDER: PXD025589 | Pride | 2024-01-26
REPOSITORIES: Pride
Solovyeva Elizaveta M EM Utzinger Stephan S Vissières Alexandra A Mitchelmore Joanna J Ahrné Erik E Hermes Erwin E Poetsch Tania T Ronco Marie M Bidinosti Michael M Merkl Claudia C Serluca Fabrizio C FC Fessenden James J Naumann Ulrike U Voshol Hans H Meyer Angelika S AS Hoersch Sebastian S
Molecular & cellular proteomics : MCP 20231121 1
Dysregulated mRNA splicing is involved in the pathogenesis of many diseases including cancer, neurodegenerative diseases, and muscular dystrophies such as myotonic dystrophy type 1 (DM1). Comprehensive assessment of dysregulated splicing on the transcriptome and proteome level has been methodologically challenging, and thus investigations have often been targeting only few genes. Here, we performed a large-scale coordinated transcriptomic and proteomic analysis to characterize a DM1 mouse model ...[more]