Proteomics

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Leucyl-tRNA synthetase is a tumor suppressor in breast cancer and enables tumor suppressive translation


ABSTRACT: In this study, we identify leucyl-tRNA synthetase (LARS) as a breast tumor suppressor. To identify the mechanism underlying LARS-mediated breast tumor suppression, we conducted TMT-proteomics in PyMT mouse tumors with monoallelic genetic deletion of LARS in the mammary tumor compartment. The analyses implicate LARS as a regulator of leucine-rich protein translation resulting in downregulation of candidate leucine-rich tumor suppressor genes.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Soren Heissel  

LAB HEAD: Sohail Tavazoie

PROVIDER: PXD026609 | Pride | 2022-01-10

REPOSITORIES: Pride

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