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Viral fallout: Semen proteome reveals COVID-19 dysregulates several biological processes linked to male reproductive function

ABSTRACT: The current global outbreak of COVID-19 has significantly impacted several organ systems. Male reproductive organs are among the potential targets of SARS-CoV-2 infection owing to the presence of abundant viral receptors; ACE2 and TMPRSS2 in the testis. However, the questions pertaining to the long term effects of SARS-CoV-2 infection on male fertility are still unanswered. For this study, we procured the semen samples of COVID-19 recovered patients and performed mass spectrometry based proteomic studies to understand the impact of the disease on the biological processes involved in reproductive health.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Semen, Sperm

DISEASE(S): Covid-19

SUBMITTER: Avinash singh

LAB HEAD: Sanjeeva Srivastava

PROVIDER: PXD026703 | Pride | 2022-04-04

REPOSITORIES: Pride

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Semen Proteomics of COVID-19 Convalescent Men Reveals Disruption of Key Biological Pathways Relevant to Male Reproductive Function.

Ghosh Susmita S Parikh Swapneil S Nissa Mehar Un MU Acharjee Arup A Singh Avinash A Patwa Dhruv D Makwana Prashant P Athalye Arundhati A Barpanda Abhilash A Laloraya Malini M Srivastava Sanjeeva S Parikh Firuza F

ACS omega 20220307 10

A considerable section of males suffered from COVID-19, with many experiencing long-term repercussions. Recovered males have been documented to have compromised fertility, albeit the mechanisms remain unclear. We investigated the impact of COVID-19 on semen proteome following complete clinical recovery using mass spectrometry. A label-free quantitative proteomics study involved 10 healthy fertile subjects and 17 COVID-19-recovered men. With 1% false discovery rate and >1 unique peptide stringenc ...[more]

PMID: 35309488

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