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Proteomic analysis of adipose tissue from a pig model of mutant INS gene induced diabetes of youth (MIDY)

ABSTRACT: To evaluate functional consequences of insulin-deficient diabetes mellitus for adipose tissue, we used a genetically engineered pig model of mutant INS gene induced diabetes of youth (MIDY). Adipose tissue samples of MIDY pigs and wild-type (WT) littermate controls were analyzed by label-free proteomics to reveal pathways and key drivers significantly affected by chronic insulin deficiency and hyperglycemia.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Mesenteric Adipose Tissue, Subcutaneous Adipose Tissue

DISEASE(S): Permanent Neonatal Diabetes Mellitus

SUBMITTER: Florian Flenkenthaler

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD026910 | Pride | 2022-02-17

REPOSITORIES: Pride

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Differential Effects of Insulin-Deficient Diabetes Mellitus on Visceral vs. Subcutaneous Adipose Tissue-Multi-omics Insights From the Munich MIDY Pig Model.

Flenkenthaler Florian F Ländström Erik E Shashikadze Bachuki B Backman Mattias M Blutke Andreas A Philippou-Massier Julia J Renner Simone S Hrabe de Angelis Martin M Wanke Rüdiger R Blum Helmut H Arnold Georg J GJ Wolf Eckhard E Fröhlich Thomas T

Frontiers in medicine 20211123

Adipose tissue (AT) is no longer considered to be responsible for energy storage only but is now recognized as a major endocrine organ that is distributed across different parts of the body and is actively involved in regulatory processes controlling energy homeostasis. Moreover, AT plays a crucial role in the development of metabolic disease such as diabetes. Recent evidence has shown that adipokines have the ability to regulate blood glucose levels and improve metabolic homeostasis. While AT h ...[more]

PMID: 34888323

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