Proteomic analysis of adipose tissue from a pig model of mutant INS gene induced diabetes of youth (MIDY)

ABSTRACT: To evaluate functional consequences of insulin-deficient diabetes mellitus for adipose tissue, we used a genetically engineered pig model of mutant INS gene induced diabetes of youth (MIDY). Adipose tissue samples of MIDY pigs and wild-type (WT) littermate controls were analyzed by label-free proteomics to reveal pathways and key drivers significantly affected by chronic insulin deficiency and hyperglycemia.

INSTRUMENT(S):

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Mesenteric Adipose Tissue, Subcutaneous Adipose Tissue

DISEASE(S): Permanent Neonatal Diabetes Mellitus

SUBMITTER: Florian Flenkenthaler  

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD026910 | Pride | 2022-02-17

REPOSITORIES: Pride