Dataset Information

The role of Rpl3l in translation in cardiomyocytes

ABSTRACT: Ribosome immunoprecipitates of cardiomyocytes isolated from Rpl3l-/- and Rpl3l+/+ mouse hearts were analysed using mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap Classic

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Regular Cardiac Myocyte

SUBMITTER: Eva Maria Novoa

LAB HEAD: Eva Maria Novoa Pardo

PROVIDER: PXD026985 | Pride | 2023-03-08

REPOSITORIES: Pride

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			Action	DRS
	2021LB000_IVMI_001_01_20pto.raw	Raw
	2021LB000_IVMI_002_01_20pto.raw	Raw
	2021LB000_IVMI_003_01_20pto.raw	Raw
	2021LB000_IVMI_004_01_20pto.raw	Raw
	2021LB000_IVMI_005_01_20pto.raw	Raw

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Publications

Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.

Milenkovic Ivan I Santos Vieira Helaine Graziele HG Lucas Morghan C MC Ruiz-Orera Jorge J Patone Giannino G Kesteven Scott S Wu Jianxin J Feneley Michael M Espadas Guadalupe G Sabidó Eduard E Hübner Norbert N van Heesch Sebastiaan S Völkers Mirko M Novoa Eva Maria EM

Nucleic acids research 20230601 11

The existence of naturally occurring ribosome heterogeneity is now a well-acknowledged phenomenon. However, whether this heterogeneity leads to functionally diverse 'specialized ribosomes' is still a controversial topic. Here, we explore the biological function of RPL3L (uL3L), a ribosomal protein (RP) paralogue of RPL3 (uL3) that is exclusively expressed in skeletal muscle and heart tissues, by generating a viable homozygous Rpl3l knockout mouse strain. We identify a rescue mechanism in which, ...[more]

PMID: 36882085

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