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Proteomic changes linked to the limbic stage of AD

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia worldwide. In AD, neurodegeneration spreads throughout the brain cortex in a gradual and predictable pattern, causing progressive memory decline and cognitive impairment. Here, we conducted proteomic, acetylomic and phosphoproteomic analyses of human postmortem tissue samples from AD (Braak stage III-IV) and control brains, covering all anatomical areas affected during the limbic stage of the disease (total hippocampus, CA1, entorhinal and perirhinal cortices). A total of 58 tissues were analyzed by nanoLC-MS/MS.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Melinda Rezeli

LAB HEAD: Gyorgy Marko-Varga

PROVIDER: PXD027173 | Pride | 2021-12-30

REPOSITORIES: Pride

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Topological Dissection of Proteomic Changes Linked to the Limbic Stage of Alzheimer's Disease.

Velásquez Erika E Szeitz Beáta B Gil Jeovanis J Rodriguez Jimmy J Palkovits Miklós M Renner Éva É Hortobágyi Tibor T Döme Péter P Nogueira Fábio Cs FC Marko-Varga György G Domont Gilberto B GB Rezeli Melinda M

Frontiers in immunology 20211012

Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia worldwide. In AD, neurodegeneration spreads throughout different areas of the central nervous system (CNS) in a gradual and predictable pattern, causing progressive memory decline and cognitive impairment. Deposition of neurofibrillary tangles (NFTs) in specific CNS regions correlates with the severity of AD and constitutes the basis for disease classification into different Braak stages (I-VI). Early ...[more]

PMID: 34712240

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