Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cholangiocarcinoma Cell, Epithelial Cell
DISEASE(S): Cholangiocarcinoma
SUBMITTER: Vinothini Rajeeve
LAB HEAD: Professor Pedro R Cutillas
PROVIDER: PXD027329 | Pride | 2023-03-11
REPOSITORIES: Pride
Khorsandi Shirin Elizabeth SE Dokal Arran D AD Rajeeve Vinothini V Britton David J DJ Illingworth Megan S MS Heaton Nigel N Cutillas Pedro R PR
Cancer research 20210922 22
Cholangiocarcinoma is a form of hepatobiliary cancer with an abysmal prognosis. Despite advances in our understanding of cholangiocarcinoma pathophysiology and its genomic landscape, targeted therapies have not yet made a significant impact on its clinical management. The low response rates of targeted therapies in cholangiocarcinoma suggest that patient heterogeneity contributes to poor clinical outcome. Here we used mass spectrometry-based phosphoproteomics and computational methods to identif ...[more]