Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Marie Alfes
LAB HEAD: Carla Schmidt
PROVIDER: PXD027408 | Pride | 2022-02-17
REPOSITORIES: Pride
Sethumadhavan Sunesh S Barth Marie M Spaapen Robbert M RM Schmidt Carla C Trowitzsch Simon S Tampé Robert R
Scientific reports 20220127 1
Major histocompatibility complex class I (MHC I) molecules present antigenic peptides to cytotoxic T cells to eliminate infected or cancerous cells. The transporter associated with antigen processing (TAP) shuttles proteasomally generated peptides into the ER for MHC I loading. As central part of the peptide-loading complex (PLC), TAP is targeted by viral factors, which inhibit peptide supply and thereby impact MHC I-mediated immune responses. However, it is still poorly understood how antigen p ...[more]