Regulated biogenesis and targeting of monotopic squalene monooxygenase requires the GET pathway

ABSTRACT: This study investigated get3 mutant yeast cell. Proteins of the GET pathway are involved in targeting of C-terminally anchored transmembrane proteins and protection against lipotoxicity. Get3 cells revealed an altered ergosterol production and susceptibility towards a sterol synthesis inhibiting drug terbinafine. Furthermore, we identified a member of a non-canonical GET pathway client, a monotopic membrane protein squalene monooxygenase Erg1 that may be responsible for the susceptibility of Get3 mutant to lipotoxic agents.

INSTRUMENT(S):

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Ivan Silbern  

LAB HEAD: Prof. Dr. Henning Urlaub

PROVIDER: PXD027705 | Pride | 2022-06-09

REPOSITORIES: Pride