Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Embryo, Cell Culture
SUBMITTER: Heya Zhao
LAB HEAD: Alexey Veraksa
PROVIDER: PXD027934 | Pride | 2023-01-17
REPOSITORIES: Pride
Zhao Heya H Moberg Kenneth H KH Veraksa Alexey A
Developmental cell 20230302 5
The canonical function of the Hippo signaling pathway is the regulation of organ growth. How this pathway controls cell-fate determination is less well understood. Here, we identify a function of the Hippo pathway in cell-fate decisions in the developing Drosophila eye, exerted through the interaction of Yorkie (Yki) with the transcriptional regulator Bonus (Bon), an ortholog of mammalian transcriptional intermediary factor 1/tripartite motif (TIF1/TRIM) family proteins. Instead of controlling t ...[more]