Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Plasmodium Falciparum (isolate 3d7)
TISSUE(S): Erythrocyte
DISEASE(S): Plasmodium Falciparum Malaria
SUBMITTER: lina chen
LAB HEAD: Lina Chen
PROVIDER: PXD028062 | Pride | 2022-02-15
REPOSITORIES: Pride
Chen Lina L Zheng Zhongyuan Z Liu Hui H Wang Xi X Qu Shuiqing S Yang Yuanmin Y Deng Shuoqiu S Zhang Yu Y Tuo Liu L Zhao Yongdan Y Li Yujie Y
Microbiology spectrum 20211215 3
Malaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation. Artemisinin combination therapies are the first-line antiplasmodials in countries of endemicity. However, the mechanism of action of artemisinin is unclear, and drug resistance decreases long-term efficacy. To understand whether artemisinin targets or interacts with iRBC membrane proteins, this study investigated the molecular changes caused by dihydroarte ...[more]