Combined transcriptome and proteome profiling for role of pfEMP1 in antimalarial mechanism of action of dihydroartemisin

ABSTRACT: Malaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation. Artemisinin combination therapies are the first-line antiplasmodials in endemic countries. However, the mechanism of action of artemisinin is unclear, and drug resistance decreases long-term efficacy. To understand whether artemisinin targets or interacts with iRBC membrane proteins, this study investigated the molecular changes caused by dihydroartemisin (DHA), an artemisinin derivative, in Plasmodium falciparum 3D7 using a combined transcriptomic and membrane proteomic profiling approach.

INSTRUMENT(S):

ORGANISM(S): Plasmodium Falciparum (isolate 3d7)

TISSUE(S): Erythrocyte

DISEASE(S): Plasmodium Falciparum Malaria

SUBMITTER: lina chen  

LAB HEAD: Lina Chen

PROVIDER: PXD028062 | Pride | 2022-02-15

REPOSITORIES: Pride