Proteomics

Dataset Information

0

Profiling of IgG N-glycome in gastric cancer by MALDI-TOF-MS


ABSTRACT: Background: Alterations in IgG glycosylation have been observed in many inflammatory activities and diseases progression, uncovering IgG glycome contributes to deciphering the molecular mechanism of human diseases. Gastric cancer (GC) associated IgG glycosylation was rarely investigated.Methods: We comprehensively characterized IgG N-glycome profile in GC by high-throughput orthogonal mass spectrometry assay, and analyzed the difference of glycosylation between controls and GC patients through multiple statistical tools. Bioinformatics analysis was performed to study the candidate glycogens and their biological functions involved in GC. Results: GC associates with decrease in galactosylation and sialylation of IgG, and increase in bisection and agalactosylation of IgG.Bioinformatics analysis verified the differential expression of significantly changed IgG glycan associated glycogens, indicating the crucial role of IgG glycosylation in the pathogenesis of GC.Conclusions: This study demonstrates the potential diagnostic merits of specific IgG glycans for early detection of GC, as well as revealing molecular mechanism in the development of this cancer.

INSTRUMENT(S): 4800 Proteomics Analyzer

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood Serum

DISEASE(S): Stomach Carcinoma

SUBMITTER: Si Liu  

LAB HEAD: Si Liu

PROVIDER: PXD028368 | Pride | 2025-05-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Benign.rar Other
Benign_GlycanFeatures.txt Txt
Benign_IndividualGlycan.txt Txt
Cancer.rar Other
Cancer_GlycanFeatures.txt Txt
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Publications

Non-thermal pasteurization of apples in syrup with dense phase carbon dioxide

Ferrentino Giovanna G   Spilimbergo Sara S  

Journal of Food Engineering. 20170801


The study investigated dense phase carbon dioxide (DPCD) applicability to a solid-liquid product consisted of apples in syrup as an alternative to the conventional thermal pasteurization. The effect of pressure (8, 10, and 12 MPa) and temperature (35, 45, and 55 °C) at 15 min was investigated to determine the inactivation of the natural microbiota (mesophilic microorganisms, total coliforms, yeasts and molds) and polyphenol oxidase enzyme. The optimal process conditions (12 MPa, 55 °C, 15 min) w  ...[more]

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