Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): T Cell
SUBMITTER: Hossein Fazelinia
LAB HEAD: Paula M. Oliver, PhD
PROVIDER: PXD028492 | Pride | 2022-06-09
REPOSITORIES: Pride
Kumar Binod B Field Natania S NS Kim Dale D DD Dar Asif A AA Chen Yanqun Y Suresh Aishwarya A Pastore Christopher F CF Hung Li-Yin LY Porter Nadia N Sawada Keisuke K Shah Palak P Elbulok Omar O Moser Emily K EK Herbert De'Broski R DR Oliver Paula M PM
Nature communications 20220519 1
Antigen encounter directs CD4<sup>+</sup> T cells to differentiate into T helper or regulatory cells. This process focuses the immune response on the invading pathogen and limits tissue damage. Mechanisms that govern T helper cell versus T regulatory cell fate remain poorly understood. Here, we show that the E3 ubiquitin ligase Cul5 determines fate selection in CD4<sup>+</sup> T cells by regulating IL-4 receptor signaling. Mice lacking Cul5 in T cells develop Th2 and Th9 inflammation and show pa ...[more]