Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Ilka Wittig
LAB HEAD: Stefanie Dimmeler
PROVIDER: PXD029794 | Pride | 2022-11-29
REPOSITORIES: Pride
Heumüller Andreas W AW Jones Alisha N AN Mourão André A Klangwart Marius M Shi Chenyue C Wittig Ilka I Fischer Ariane A Muhly-Reinholz Marion M Buchmann Giulia K GK Dieterich Christoph C Potente Michael M Braun Thomas T Grote Phillip P Jaé Nicolas N Sattler Michael M Dimmeler Stefanie S
Circulation research 20211118 1
<h4>Background</h4>Circular RNAs (circRNAs) are generated by back splicing of mostly mRNAs and are gaining increasing attention as a novel class of regulatory RNAs that control various cellular functions. However, their physiological roles and functional conservation in vivo are rarely addressed, given the inherent challenges of their genetic inactivation. Here, we aimed to identify locus conserved circRNAs in mice and humans, which can be genetically deleted due to retained intronic elements no ...[more]