Mapping of TDP-43 ubiquitination and acetylation sites

ABSTRACT: TAR DNA binding protein of 43 kDa (TDP-43) forms aggregates in neurodegenerative diseases, particularly certain forms of frontotemporal dementia and amyotrophic lateral sclerosis. Pathological modifications of TDP-43 include proteolytic fragmentation, phosphorylation, and ubiquitinylation. In this study, we systematically mapped TDP-42 ubiquitination as well as acetylation sites.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Frontotemporal Dementia,Amyotrophic Lateral Sclerosis

SUBMITTER: Christian Johannes Gloeckner  

LAB HEAD: Christian Johannes Gloeckner

PROVIDER: PXD030170 | Pride | 2022-04-01

REPOSITORIES: Pride