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Multi-omics analysis into the molecular mechanisms underlying the up-regulation of HBG1/2 expression induced by HBB deletion

ABSTRACT: A multi-omics study examining chromatin accessibility, transcriptome, proteome and phosphorylation patterns in the HBB homozygous knockout of the HUDEP2 cell line (HBB-KO)

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Mixed Disorder As Reaction To Stress

SUBMITTER: Guoqiang Zhou

LAB HEAD: Daru Lu

PROVIDER: PXD030182 | Pride | 2022-04-04

REPOSITORIES: Pride

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Multi-Omics Analysis in β-Thalassemia Using an HBB Gene-Knockout Human Erythroid Progenitor Cell Model.

Zhou Guoqiang G Zhang Haokun H Lin Anning A Wu Zhen Z Li Ting T Zhang Xumin X Chen Hongyan H Lu Daru D

International journal of molecular sciences 20220304 5

β-thalassemia is a hematologic disease that may be associated with significant morbidity and mortality. Increased expression of HBG1/2 can ameliorate the severity of β-thalassemia. Compared to the unaffected population, some β-thalassemia patients display elevated HBG1/2 expression levels in their red blood cells. However, the magnitude of up-regulation does not reach the threshold of self-healing, and thus, the molecular mechanism underlying HBG1/2 expression in the context ...[more]

PMID: 35269949

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