Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Anemia Mus Musculus (mouse)
TISSUE(S): Cell Culture, Early Embryonic Cell
SUBMITTER: Sophe Alvarez
LAB HEAD: Sophie Alvarez
PROVIDER: PXD030467 | Pride | 2022-08-09
REPOSITORIES: Pride
Ray Suhita S Chee Linda L Zhou Yichao Y Schaefer Meg A MA Naldrett Michael J MJ Alvarez Sophie S Woods Nicholas T NT Hewitt Kyle J KJ
eLife 20220617
Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals-involving cooperation between stem cell factor (SCF)/Kit signaling and other signaling inputs-are required for the increased erythroid precursor activity in anemia. Our prior work revealed that the sterile alpha motif (SAM) domain 14 (<i>Samd14</i>) gene increases the regenerative capacity of the erythroid system in a mouse genetic model and promotes stress-de ...[more]