Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Pei Liu
LAB HEAD: Ron Mittler
PROVIDER: PXD030509 | Pride | 2022-08-12
REPOSITORIES: Pride
Sohn Yang Sung YS Losub-Amir Anat A Cardenas Alfredo E AE Karmi Ola O Yahana Merav Darash MD Gruman Tal T Rowland Linda L Marjault Henri-Baptiste HB Webb Lauren J LJ Mittler Ron R Elber Ron R Friedler Assaf A Nechushtai Rachel R
Chemical science 20220526 23
An effective anti-cancer therapy should exclusively target cancer cells and trigger in them a broad spectrum of cell death pathways that will prevent avoidance. Here, we present a new approach in cancer therapy that specifically targets the mitochondria and ER of cancer cells. We developed a peptide derived from the flexible and transmembrane domains of the human protein NAF-1/CISD2. This peptide (NAF-1<sup>44-67</sup>) specifically permeates through the plasma membranes of human epithelial brea ...[more]