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High fat diet feed mice liver sample proteomics

ABSTRACT: determine the effect of the high-fat diet on the proteomics profile of liver tissue.Mice were fed with HFD for 16 weeks to establish a NAFLD mouse model. Mice fed with normal chow diet were taken as controls. Five replicate liver samples were collected from each group for proteomics analysis.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

DISEASE(S): Non-alcoholic Fatty Liver Disease

SUBMITTER: Zhi Shang

LAB HEAD: Zhi Shang

PROVIDER: PXD030727 | Pride | 2022-06-09

REPOSITORIES: Pride

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Quantitative proteomics of HFD-induced fatty liver uncovers novel transcription factors of lipid metabolism.

Zhi Shang S Congcong Zhang Z Zhiling Gao G Yihan Qian Q Yijing Xin X Guanjie Liu L Fang Wang W Xuehua Sun S Hongjie Li L Xiaoni Kong K Yueqiu Gao G

International journal of biological sciences 20220501 8

Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease, which progression is tightly regulated by transcription factors (TFs), nuclear receptors, and cellular enzymes. In this study, a label-free quantitative proteomic approach was used to determine the effect of the high-fat diet on the proteomics profile of liver tissue and to identify novel NAFLD related TFs. Mice were fed with HFD for 16 weeks to establish a NAFLD mouse model. Mice fed with normal chow diet ...[more]

PMID: 35637971

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