GBA1 interactome for understanding pathological mechanisms

ABSTRACT: Compound heterozygous or homozygous GBA1 mutations lead to Gaucher disease. Furthermore, GBA1 mutations are the most frequent risk factor for Parkinson’s disease. To get a better understanding of the pathological mechanisms, we generated inducible V5-Flag-Tag, V5-Flag-tagged WT, E326K and L444P mutant Flp-In™T-REx™-HEK293 and performed interatomic analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Frank Stein  

LAB HEAD: Michela Deleidi

PROVIDER: PXD032155 | Pride | 2023-05-10

REPOSITORIES: Pride