Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Plasma, Kidney, Renal Glomerulus
DISEASE(S): Membranous Glomerulonephritis
SUBMITTER: Frank Stein
LAB HEAD: Prof. Rolf A.K. Stahl
PROVIDER: PXD032713 | Pride | 2022-08-03
REPOSITORIES: Pride
Reinhard Linda L Machalitza Maya M Wiech Thorsten T Gröne Hermann-Josef HJ Lassé Moritz M Rinschen Markus M MM Ferru Nicoletta N Bräsen Jan Hinrich JH Drömann Friederike F Rob Peter Maria PM Sethi Sanjeev S Hoxha Elion E Stahl Rolf A K RAK
Journal of the American Society of Nephrology : JASN 20220819 10
<h4>Background</h4>Primary membranous nephropathy (MN) is caused by circulating autoantibodies binding to antigens on the podocyte surface. PLA<sub>2</sub>R1 is the main target antigen in 70%-80% of cases, but the pathogenesis is unresolved in 10%-15% of patients.<h4>Methods</h4>We used native western blotting to identify IgG4 autoantibodies, which bind an antigen endogenously expressed on podocyte membranes, in the serum of the index patient with MN. These IgG4 autoantibodies were used to immun ...[more]