The pivotal and universal role of BGLT3 lncRNA in fetal globin gene expression

ABSTRACT: A highly selective and non-genotoxic G9a inhibitor, RK-701 was discovered, which upregulated the mRNA level of γ-globin but not β-globin both in human erythroid cells and in mice. Using RK-701, we examined the induction of the fetal (γ-) globin protein in human erythroid cells; HUDEP-2 and human CD34+ bone marrow and peripheral blood cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Erythrocyte, Cell Culture

DISEASE(S): Sickle Cell Anemia

SUBMITTER: Masaya Usui  

LAB HEAD: Akihiro Ito

PROVIDER: PXD033536 | Pride | 2023-03-11

REPOSITORIES: Pride