Transcriptional environment and chromatin modifications interplay decides globin expression patterns.

ABSTRACT: Background: Developmental stage-specific globin expression is a complex phenomenon that involves both trans- and cis-acting elements. While functional analyses ensuing recent genome-wide association studies have highlighted the important roles of trans-factors in regulating hemoglobin expression, these factors can not exert their functions without permissive chromatin domains. By transferring thoroughly profiled beta globin locus of undifferentiated human embryonic stem cells (hESCs) or hESC-derived erythroid cells into an adult erythroid transcriptional environment, we studied the influences of histone modifications on the globin expression decision within a fixed transcriptional environment. Shortly after the locus transfer, embryonic epsilon globin was not expressed regardless of origin

ORGANISM(S): Homo sapiens

SUBMITTER: Richard Beyer 

PROVIDER: E-GEOD-31523 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress