Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Heart, Regular Ventricular Cardiac Myocyte, Fetal Cardiomyocyte
DISEASE(S): Disease Free
SUBMITTER: Duangnapa Kovanich
LAB HEAD: Manuela Zaccolo
PROVIDER: PXD033773 | Pride | 2023-03-10
REPOSITORIES: Pride
Circulation research 20230308 7
<h4>Background</h4>Signaling by cAMP is organized in multiple distinct subcellular nanodomains regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac β-adrenergic signaling has served as the prototypical system to elucidate cAMP compartmentalization. Although studies in cardiac myocytes have provided an understanding of the location and properties of a handful of cAMP subcellular compartments, an overall view of the cellular landscape of cAMP nanodomains is missing.<h4>Methods</h4>Here ...[more]