Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Trypanosoma Brucei
TISSUE(S): Cell Culture
SUBMITTER: MARIA BEZERRA
LAB HEAD: Osvaldo Pompílio de Melo Neto
PROVIDER: PXD033857 | Pride | 2023-03-10
REPOSITORIES: Pride
Bezerra Maria J R MJR Moura Danielle M N DMN Freire Eden R ER Holetz Fabiola B FB Reis Christian R S CRS Monteiro Tallyta T S TTS Pinto Adriana R S ARS Zhang Ning N Rezende Antonio M AM Pereira-Neves Antonio A Figueiredo Regina C B Q RCBQ Clayton Christine C Field Mark C MC Carrington Mark M de Melo Neto Osvaldo P OP
Frontiers in molecular biosciences 20221007
Gene expression in pathogenic protozoans of the family Trypanosomatidae has several novel features, including multiple eIF4F-like complexes involved in protein synthesis. The eukaryotic eIF4F complex, formed mainly by eIF4E and eIF4G subunits, is responsible for the canonical selection of mRNAs required for the initiation of mRNA translation. The best-known complexes implicated in translation in trypanosomatids are based on two related pairs of eIF4E and eIF4G subunits (EIF4E3/EIF4G4 and EIF4E4/ ...[more]