Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Plasma
SUBMITTER: Diego Butera
LAB HEAD: Philip John Hogg
PROVIDER: PXD034866 | Pride | 2023-07-20
REPOSITORIES: Pride
Blood advances 20230501 10
von Willebrand factor (VWF) is the protective carrier of procoagulant factor VIII (FVIII) in the shear forces of the circulation, prolonging its half-life and delivering it to the developing thrombus. Using force spectroscopy, VWF-FVIII complex formation is characterized by catch-bond behavior in which force first decelerates then accelerates bond dissociation. Patients with mutations in VWF at the FVIII binding site phenocopies hemophilia A and the most common mutations are of cysteine residues ...[more]