Proteolytic degradation is the culprit behind a bioprosthetic heart valve failure
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ABSTRACT: Whereas the risk factors for structural valve deterioration (SVD) of glutaraldehyde (GA)- treated bioprosthetic heart valves (BHVs) are well-studied, those responsible for the failure of next-generation BHVs fixed with alternative chemicals remain largely unknown. Here, we collected 11 ethylene glycol diglycidyl ether (EGDE)-treated BHVs excised because of SVD and 5 calcified aortic valves (AVs) replaced with BHVs due to the calcific aortic valve disease (CAVD), further deciphering their proteomic profile.
INSTRUMENT(S): maXis
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Aortic Valve
SUBMITTER: Arseniy Lobov
LAB HEAD: Anton G. Kutikhin
PROVIDER: PXD035113 | Pride | 2022-12-25
REPOSITORIES: Pride
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