Proteolytic degradation is the culprit behind a bioprosthetic heart valve failure

ABSTRACT: Whereas the risk factors for structural valve deterioration (SVD) of glutaraldehyde (GA)- treated bioprosthetic heart valves (BHVs) are well-studied, those responsible for the failure of next-generation BHVs fixed with alternative chemicals remain largely unknown. Here, we collected 11 ethylene glycol diglycidyl ether (EGDE)-treated BHVs excised because of SVD and 5 calcified aortic valves (AVs) replaced with BHVs due to the calcific aortic valve disease (CAVD), further deciphering their proteomic profile.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Aortic Valve

SUBMITTER: Arseniy Lobov  

LAB HEAD: Anton G. Kutikhin

PROVIDER: PXD035113 | Pride | 2022-12-25

REPOSITORIES: Pride