Proteomics

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Data in support of TNF inhibition in experimental rotator cuff tear mouse model

ABSTRACT: Musculoskeletal injuries related to the rotator cuff (RC) are frequent and account for up to 70% of shoulder pain problems. Lesions of the RC lead to weakness and pain (ref: Carr et al mfl) and untreated these lesions are acompanied by muscle degeneration modulated by inflammatory reactions that vary in intensity. Anti-inflammatory modalities such as NSAID and corticosteroids are commonly used as add ons to conservative treatment of RC tendon tears or RC tendon surgery, which are, however associated with high failure rates. The aim was to study the impact that a conventional TNF inhibitor and a super selective TNF inhibitor (Anti-TNF treatment) has on soft tissue inflammation and bone constituent parameters/connective tissue in a rotator cuff tear model.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle Fiber

DISEASE(S): Musculoskeletal System Disease

SUBMITTER: Allan Stensballe  

LAB HEAD: Allan Stensballe

PROVIDER: PXD035331 | Pride | 2026-01-12

REPOSITORIES: Pride

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Action DRS
LHF3-10c_GA6_01_452.d.zip Other
LHF3-11i_GA8_01_418.d.zip Other
LHF3-11i_GB9_01_432.d.zip Other
LHF3-13I_GA1_01_333.d.zip Other
LHF3-13I_GB1_01_355.d.zip Other
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Publications

The effect of the nonselective TNF inhibitor etanercept and of the selective TNF inhibitor XPro1595 on lesioned supraspinatus muscle.

Aboo Christopher C   Lambertsen Kate Lykke KL   Nasseri Sohail S   Ding Ming M   Jensen Peter Toft PT   Linh Ta Thi My TM   Ditzel Nicholas N   Schrøder Henrik Daa HD   Stensballe Allan A   Hejbøl Eva Kildall EK   Frich Lars Henrik LH  

Bioscience reports 20251201 12

The cytokine tumor necrosis factor (TNF), a major regulator of inflammatory responses, exists in both a membrane-bound form and a soluble form. We used the nonselective TNF inhibitor etanercept and the selective inhibitor XPro1595 and compared supraspinatus muscle cytokine levels, histology, and proteomic signatures in mice after supraspinatus tendon tear. The aim was to investigate the effect of anti-TNF treatment on the early inflammatory response in the muscle after tendon tear. In addition,  ...[more]

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