Proteomics

Dataset Information

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Comparison of saliva from healthy and patients with dental erosion


ABSTRACT: To compare the salivary proteins from healthy and dental erosion patients to determine if there is an absence of proteins forming the enamel pellicle that may reduce their protection from acid erosion

INSTRUMENT(S): LTQ Orbitrap Velos Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Saliva

SUBMITTER: Steven Lynham  

LAB HEAD: Prof. Guy Carpenter

PROVIDER: PXD035565 | Pride | 2023-05-10

REPOSITORIES: Pride

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Publications

Novel bacterial proteolytic and metabolic activity associated with dental erosion-induced oral dysbiosis.

Cleaver Leanne M LM   Carda-Diéguez Miguel M   Moazzez Rebeca R   Carpenter Guy H GH  

Microbiome 20230331 1


<h4>Background</h4>Dental erosion is a disease of the oral cavity where acids cause a loss of tooth enamel and is defined as having no bacterial involvement. The tooth surface is protected from acid attack by salivary proteins that make up the acquired enamel pellicle (AEP). Bacteria have been shown to readily degrade salivary proteins, and some of which are present in the AEP. This study aimed to explore the role of bacteria in dental erosion using a multi-omics approach by comparing saliva col  ...[more]

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