Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Serum
SUBMITTER: Tamar Ziv
LAB HEAD: Carmit Levy
PROVIDER: PXD035648 | Pride | 2023-03-11
REPOSITORIES: Pride
Sheinboim Danna D Parikh Shivang S Manich Paulee P Markus Irit I Dahan Sapir S Parikh Roma R Stubbs Elisa E Cohen Gali G Zemser-Werner Valentina V Bell Rachel E RE Ruiz Sara Arciniegas SA Percik Ruth R Brenner Ronen R Leibou Stav S Vaknine Hananya H Arad Gali G Gerber Yariv Y Keinan-Boker Lital L Shimony Tal T Bikovski Lior L Goldstein Nir N Constantini Keren K Labes Sapir S Mordechai Shimonov S Doron Hila H Lonescu Ariel A Ziv Tamar T Nizri Eran E Choshen Guy G Eldar-Finkelman Hagit H Tabach Yuval Y Helman Aharon A Ben-Eliyahu Shamgar S Erez Neta N Perlson Eran E Geiger Tamar T Ben-Zvi Danny D Khaled Mehdi M Gepner Yftach Y Levy Carmit C
Cancer research 20221101 22
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism behind this relationship remains mostly unknown. Here we report that exercise induces the metabolic reprogramming of internal organs that increases nutrient demand and protects against metastatic colonization by limiting nutrient availability to the tumor, generating an exercise-induced metabolic shield. Proteomic and ex vivo metabolic capacity analyses of murine internal organs revealed that exercise induces catabol ...[more]