Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: Sara Larsen
LAB HEAD: Michael Lund Nielsen
PROVIDER: PXD035661 | Pride | 2023-10-24
REPOSITORIES: Pride
Richards Frederick F Llorca-Cardenosa Marta J MJ Langton Jamie J Buch-Larsen Sara C SC Shamkhi Noor F NF Sharma Abhishek Bharadwaj AB Nielsen Michael L ML Lakin Nicholas D ND
Nature communications 20230718 1
Although Poly(ADP-ribose)-polymerases (PARPs) are key regulators of genome stability, how site-specific ADP-ribosylation regulates DNA repair is unclear. Here, we describe a novel role for PARP1 and PARP2 in regulating Rad52-dependent replication fork repair to maintain cell viability when homologous recombination is dysfunctional, suppress replication-associated DNA damage, and maintain genome stability. Mechanistically, Mre11 and ATM are required for induction of PARP activity in response to r ...[more]