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Targeting kinome reprogramming in ESR1 fusion-driven breast cancer

ABSTRACT: Multiplexed, deep-scale LC-MSMS analysis for proteome and phosphoproteome expression profile and the targeted LC-MSMS analysis for kinases in enriched kinome of the ER+ breast cancer patient-derived xenograft tumors.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Breast

DISEASE(S): Breast Cancer

SUBMITTER: Meggie Young

LAB HEAD: Charles E. Foulds

PROVIDER: PXD036644 | Pride | 2023-10-24

REPOSITORIES: Pride

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Kinome Reprogramming Is a Targetable Vulnerability in ESR1 Fusion-Driven Breast Cancer.

Gou Xuxu X Kim Beom-Jun BJ Anurag Meenakshi M Lei Jonathan T JT Young Meggie N MN Holt Matthew V MV Fandino Diana D Vollert Craig T CT Singh Purba P Alzubi Mohammad A MA Malovannaya Anna A Dobrolecki Lacey E LE Lewis Michael T MT Li Shunqiang S Foulds Charles E CE Ellis Matthew J MJ

Cancer research 20231001 19

Transcriptionally active ESR1 fusions (ESR1-TAF) are a potent cause of breast cancer endocrine therapy (ET) resistance. ESR1-TAFs are not directly druggable because the C-terminal estrogen/anti-estrogen-binding domain is replaced with translocated in-frame partner gene sequences that confer constitutive transactivation. To discover alternative treatments, a mass spectrometry (MS)-based kinase inhibitor pulldown assay (KIPA) was deployed to identify druggable kinases that are upregulated by diver ...[more]

PMID: 37071495

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