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Immunotherapeutic antibodies derived from human tumor tertiary lymphoid structures

ABSTRACT: We report that intratumoral Tertiary Lymphoid Structures (TLS) in human ovarian cancer contain highly oligoclonal B cells that produce IgA and IgG. Using a recombinant antibody cloned from the dominant sequence of an ovarian cancer TLS, we abrogated the growth of the autologous human tumor in vivo, through recognition of the extracellular domain of tumor-promoting GPR85. TLS-derived antibodies therefore contribute to anti-tumor immunity, which could be leveraged for novel immunotherapies.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Ovary

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: John Koomen

LAB HEAD: Jose Conejo-Garcia

PROVIDER: PXD036740 | Pride | 2026-06-12

REPOSITORIES: Pride

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			Action	DRS
	22607Lysate_22607-kappa_1.raw	Raw
	22607Lysate_22607-kappa_1.raw__F002962_.dta	Raw
	22607Lysate_22607-kappa_1.raw__F002962_.mzid.gz	Mzid
	22607Lysate_22607-kappa_1.raw__F002962_.mzid_22607Lysate_22607-kappa_1.raw__F002962_.MGF	Mzid
	22607Lysate_22607-kappa_2.raw	Raw

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