Dataset Information

Global profiling of protein lysine lactylation in hepatocellular carcinoma

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common types of tumors in adults, with an estimated 740,000 people dying every year. The characteristics of lactic acid protein modifications in HCC remain unknown. Our research team, through the whole protein high flux lactic acid group, study analyses 3 cases of normal liver tissue, 3 cases were followed up for 3 years not metastatic HCC tissue, 3 cases of HCC metastasis tumors that spread to the lungs, has presented the integrity of the generation of HCC and lung metastasis lactic acid modified map, in order to find protein lactate modification targets related to HCC formation and lung metastasis in the future. Protein lactation (Kla) is a novel type of PTM discovered in 2019. Lactate, the end-product of glycolysis, is both metabolite and a signaling molecule. Moreover, studies have shown that lactic acid serves as both an energy source for tumor tissues and mediates histone lysine lactation as a modification substrate. Protein lactate modification has been shown to play a role in inflammation, neurodevelopment, and the occurrence and development of tumors

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: Xianliang Ma

LAB HEAD: Yin Yuan

PROVIDER: PXD037371 | Pride | 2025-04-07

REPOSITORIES: Pride

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			Action	DRS
	QE_HFX_20211228_50cm_60min_01.raw	Raw
	QE_HFX_20211228_50cm_60min_02.raw	Raw
	QE_HFX_20211228_50cm_60min_03.raw	Raw
	QE_HFX_20211228_50cm_60min_04.raw	Raw
	QE_HFX_20211228_50cm_60min_05.raw	Raw

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Publications

Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.

Hong Han H Chen Xi X Wang Honggang H Gu Xiangqian X Yuan Yin Y Zhang Zixiang Z

Proteomics 20230118 9

Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, often metastasizes to the lungs. The implications of lysine lactylation (Kla), a recently identified histone post-translational modification (PTM), in the pathology of HCC remain unclear. Here, we report the first proteomic survey of this specific modification in HCC (with no metastasis during 3 years of follow-up), normal liver tissues, and lung metastasis samples of HCC. Of the 2045 modification sites detected on 960 ...[more]

PMID: 36625413

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