Cellular quiescence uncouples the proteome from the transcriptome

ABSTRACT: Neural stem cells (NSCs) are multipotent cells in the central nervous system which can self-renew, differentiate or reversibly exit the cell cycle to enter a dormat state known as quiescence. To study the molecular mechanisms underpinning this state we use an in vitro model of NSC quiescence, which uses adult hippocampal NSCs harvested from mice. In this cell culture system, we are able to reversibly induce quiescence by supplementing the media with BMP4. In this study we examine how the proteome changes as NSCs transition from an active state (proliferating, 0d BMP4) into quiescence (up to 21 days in BMP4).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Stem Cell

SUBMITTER: Mark Skehel  

LAB HEAD: Francois Guillemot

PROVIDER: PXD037487 | Pride | 2026-03-09

REPOSITORIES: Pride