Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: jianqiang Mu
LAB HEAD: Zhongmin LIU
PROVIDER: PXD037493 | Pride | 2023-05-10
REPOSITORIES: Pride
Action | DRS | |||
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ATP13A2-WT_Crosslink.csv | Csv | |||
ATP13A2-WT_Looplink.csv | Csv | |||
ATP13A2-WT_Monolink.csv | Csv | |||
ATP13A2-WT_SPM.csv | Csv | |||
ATP13A2_Q9NQ11-1_.fasta | Fasta |
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Mu Jianqiang J Xue Chenyang C Fu Lei L Yu Zongjun Z Nie Minhan M Wu Mengqi M Chen Xinmeng X Liu Kun K Bu Ruiqian R Huang Ying Y Yang Baisheng B Han Jianming J Jiang Qianru Q Chan Kevin C KC Zhou Ruhong R Li Huilin H Huang Ancheng A Wang Yong Y Liu Zhongmin Z
Nature communications 20230408 1
Dysregulation of polyamine homeostasis strongly associates with human diseases. ATP13A2, which is mutated in juvenile-onset Parkinson's disease and autosomal recessive spastic paraplegia 78, is a transporter with a critical role in balancing the polyamine concentration between the lysosome and the cytosol. Here, to better understand human ATP13A2-mediated polyamine transport, we use single-particle cryo-electron microscopy to solve high-resolution structures of human ATP13A2 in six intermediate ...[more]