Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human) Mycobacterium Tuberculosis H37rv
TISSUE(S): Macrophage
DISEASE(S): Tuberculosis
SUBMITTER: Owen Leddy
LAB HEAD: Forest White
PROVIDER: PXD037837 | Pride | 2023-04-24
REPOSITORIES: Pride
Leddy Owen K OK White Forest M FM Bryson Bryan D BD
mSystems 20210803 4
T cells must recognize pathogen-derived peptides bound to major histocompatibility complexes (MHCs) in order to initiate a cell-mediated immune response against an infection, or to support the development of high-affinity antibody responses. Identifying antigens presented on MHCs by infected cells and professional antigen-presenting cells (APCs) during infection may therefore provide a route toward developing new vaccines. Peptides bound to MHCs can be identified at whole-proteome scale using ma ...[more]