Proteomics

Dataset Information

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4D label-free quantitative proteomics analyses of peritoneal extracellular vesicles isolated from normal mice and peritoneal dialysis fluid-treated mice


ABSTRACT: Peritoneal fibrosis is regard as a significant cause of the loss of peritoneal function, markedly limiting the application of peritoneal dialysis(PD). However, the pathogenesis of peritoneal fibrosis remains unclear. Tissue-derived extracellular vesicles(EVs) mediate intercellular communications and play a central role in organ fibrosis. We performed a proteomics profiling of EVs from normal peritoneum and PD-induced fibrotic peritoneum in mice.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Peritoneum

SUBMITTER: qiang huang  

LAB HEAD: hui peng

PROVIDER: PXD037945 | Pride | 2023-01-25

REPOSITORIES: Pride

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Publications

Proteomic Characterization of Peritoneal Extracellular Vesicles in a Mouse Model of Peritoneal Fibrosis.

Huang Qiang Q   Sun Yuxiang Y   Sun Juan J   Peng Long L   Shang Hongli H   Wei Dandan D   Li Canming C   Hu Zhaoyong Z   Peng Hui H  

Journal of proteome research 20230117 3


Peritoneal fibrosis progression is regarded as a significant cause of the loss of peritoneal function, markedly limiting the application of peritoneal dialysis (PD). However, the pathogenesis of peritoneal fibrosis remains to be elucidated. Tissue-derived extracellular vesicles (EVs) change their molecular cargos to adapt the environment alteration, mediating intercellular communications and play a significant role in organ fibrosis. Hence, we performed, for the first time, four-dimensional labe  ...[more]

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