Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Gallus Gallus (chicken)
SUBMITTER: Florian Stengel
LAB HEAD: Florian Stengel
PROVIDER: PXD038153 | Pride | 2023-08-01
REPOSITORIES: Pride
Goretzki Benedikt B Wiedemann Christoph C McCray Brett A BA Schäfer Stefan L SL Jansen Jasmin J Tebbe Frederike F Mitrovic Sarah-Ana SA Nöth Julia J Cabezudo Ainara Claveras AC Donohue Jack K JK Jeffries Cy M CM Steinchen Wieland W Stengel Florian F Sumner Charlotte J CJ Hummer Gerhard G Hellmich Ute A UA
Nature communications 20230713 1
Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large N-terminal IDR of approximately 150 amino acids. With an integrated structural biology approach, we analyze the structural ensemble of the TRPV4 IDR and the network of antagonistic regulatory elements it encodes. These modulate channel activity in a hierarchi ...[more]