Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Dendritic Cell
SUBMITTER: Inmaculada Jorge
LAB HEAD: Jesús Vázquez Cobos
PROVIDER: PXD039035 | Pride | 2024-01-26
REPOSITORIES: Pride
Calzada-Fraile Diego D Iborra Salvador S Ramírez-Huesca Marta M Jorge Inmaculada I Dotta Enrico E Hernández-García Elena E Martín-Cófreces Noa N Nistal-Villán Estanislao E Veiga Esteban E Vázquez Jesús J Pasqual Giulia G Sánchez-Madrid Francisco F
Nature communications 20231025 1
Antigen cognate dendritic cell (DC)-T cell synaptic interactions drive activation of T cells and instruct DCs. Upon receiving CD4<sup>+</sup> T cell help, post-synaptic DCs (psDCs) are licensed to generate CD8<sup>+</sup> T cell responses. However, the cellular and molecular mechanisms that enable psDCs licensing remain unclear. Here, we describe that antigen presentation induces an upregulation of MHC-I protein molecules and increased lipid peroxidation on psDCs in vitro and in vivo. We also sh ...[more]