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Pathogenic Bacteria Exploit Transferrin Receptor Transcytosis to Penetrate the Blood‒Brain Barrier

ABSTRACT: In this study, we present evidence showing that the infection with the major meningitis-causing bacteria, NMEC, GBS and SPN, activates the same fusion process of bacteria-containing vesicles (BCVs) with TfR vesicles, which enables those bacteria to exploit TfR transcytosis to penetrate the BBB, and illustrate the details of this process in HBMECs and mouse models.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: yang wen

LAB HEAD: Wang Lei

PROVIDER: PXD039060 | Pride | 2023-10-24

REPOSITORIES: Pride

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Pathogenic bacteria exploit transferrin receptor transcytosis to penetrate the blood-brain barrier.

Cheng Zhihui Z Zheng Yangyang Y Yang Wen W Sun Hongmin H Zhou Fangyu F Huang Chuangjie C Zhang Shuwen S Song Yingying Y Liang Qi'an Q Yang Nan N Li Meifang M Liu Bin B Feng Lu L Wang Lei L

Proceedings of the National Academy of Sciences of the United States of America 20230921 39

The human blood-brain barrier (BBB) comprises a single layer of brain microvascular endothelial cells (HBMECs) protecting the brain from bloodborne pathogens. Meningitis is among the most serious diseases, but the mechanisms by which major meningitis-causing bacterial pathogens cross the BBB to reach the brain remain poorly understood. We found that Streptococcus pneumoniae, group B Streptococcus, and neonatal meningitis Escherichia coli commonly exploit a unique vesicle fus ...[more]

PMID: 37733740

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