Dataset Information
Type I interferon/STAT1 signaling negative feedback regulates UBE2M-mediated antiviral innate immunity
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Epithelial Cell, Cell Culture, Fibroblast
DISEASE(S): Influenza
SUBMITTER: 
Xianghui Kong
LAB HEAD: Zhijian Cai
PROVIDER: PXD039071 | Pride | 2023-01-30
REPOSITORIES: Pride
Publications
Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner.
Cell reports 20230119 1
Type I interferon (IFN-I) signaling is central to inducing antiviral innate immunity. However, the mechanisms for IFN-I signaling self-regulation are still largely unknown. Here, we report that RNA virus-infected macrophages with UBE2M deficiency produced decreased IFN-I expression in a RIG-I-dependent manner, causing an aggravated viral infection. Mechanistically, UBE2M inhibits RIG-I degradation by preventing the interaction of RIG-I and E3 ligase STUB1, resulting in antiviral IFN-I signaling ...[more]
